602-06

175-178

                                                      Preventing Estrus

• Ovaban is megestrol acetate, a synthetic progesterone.
• As of 2002 this product was no longer available
• 9/28/04 - Available at: 
  • Cornerstone Pharmacy and Compounding Lab
  • 100 South Main St. 
  • Versailles, KY 40383  
  • 877-581-8828

To prevent estrus

• To prevent estrus administer 0.25 mg/lb for 32 days. A maximum of 32 days is approved by the manufacturer. To prevent the next cycle start at least 1 week before the next anticipated estrus cycle. The next heat will be in 4-5 months if the Ova-Ban is given shortly before the next heat will occur.
• If the Ovaban is given during diestrus (for example, the client did not know what stage the bitch was in) the next cycle will be at the regularly anticipated time.

• The drug is 97 % effective at preventing estrus.
• There is no apparent effect on fertility

• The bitch must be in first 3 days of proestrus to be effective.
• Administer 1 mg/lb/day for 8 days.
• The next estrous cycle will be 4-6 weeks earlier than the heat normally would have been.

• If the bitch should be bred during the first 3 days of treatment, consider mismate management. If the bitch is bred after 3 days of treatment, pregnancy is unlikely to occur.
• The drug is 92 % effective at preventing the estrus if the bitch is in the first 3 days of proestrus.

• Depoprovera is long acting injectable progestagen. It has been taken off the veterinary market, but is still available on human market.
• Administration predisposes to pyometra.

• All injectable progesterone predispose the bitch to cystic endometrial hyperplasia (CEH) and pyometra.

• Cheque drops may be available in the US at this time (October 2004).
  • Road Runner Pharmacy  - 877-518-4589
  • Premier Pharmacy
    • www.premierpharmacylabs.com
  • Were at Wedgewood pharmacy (not as of August 2004)
    • 373-K Egg Harbor Rd.
    • Sewell, NJ 08080
    • 609-5894200
    •  (http://www.wedgewoodpharmacy.com/contact.asp)  is listed on their site as:"Mibolerone 100ug/ml 55ml Sol"

   

• Cheque drops are 'mibolerone', an androgen.

• The androgen blocks LH release, therefore preventing estrus.
• It is advised not to give before first heat because it will cause premature physeal closure.
• You must start treatment at least 30 days before the next anticipated heat.

Dose schedule

• It has been approved for a maximum of 24 months, but it has been given as long as 43 months experimentally without causing problems.
• The next heat will be in 7 - 200 days (i.e. unpredictable) and will be of lowered fertility.
• If pregnancy does occur, any female pups will be masculinized.
• May cause clitoral hypertrophy (tail lighters).
• Fertility reported as normal on first estrus.
• It is not for breeding bitches

Testosterone

• Testosterone is routinely used in greyhound kennels to prevent estrus.
• Procurement is more difficult now due to abuse by athletes.

.
 

• Oral - Methyl testosterone- 5 mg/wk (or give ½ the dose, 2X/wk)
• Parenteral - Testosterone propionate - 100mg/ml preparation, 25 mg IM (in the pectorals) every 2 wks
• May take several months to have an estrous cycle.

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of Approved Animal Drugs